Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs
Author(s) -
McDermott,
Keping Xu,
Linda Villanueva,
Rhett M. Schiffman,
David Hollander
Publication year - 2011
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s16778
Subject(s) - ketorolac , medicine , ketorolac tromethamine , wound healing , nonsteroidal , tolerability , ophthalmology , anesthesia , pharmacology , surgery , adverse effect , analgesic
Ketorolac 0.45% is a new formulation of topical ketorolac in which preservative (benzalkonium chloride, BAK) was removed and carboxymethylcellulose (CMC) was added to improve tolerability and reduce dosing frequency. This study compared the effects of ketorolac 0.45% on corneal wound healing to prior ketorolac formulations (0.4% and 0.5%), bromfenac 0.09%, and nepafenac 0.1%.
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