Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wet AMD | Zendy

Daniele Tognetto | Zendy; Skiadaresi | Zendy; Paolo Cecchini | Zendy; Guiseppe Ravalico | Zendy

Open Access

Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wet AMD

Author(s) -

Daniele Tognetto,

Skiadaresi,

Paolo Cecchini,

Guiseppe Ravalico

Publication year - 2011

Publication title -

clinical ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 56

eISSN - 1177-5483

pISSN - 1177-5467

DOI - 10.2147/opth.s15864

Subject(s) - medicine , recombinant tissue plasminogen activator , ophthalmology , tissue plasminogen activator , ischemic stroke , ischemia , modified rankin scale

We describe three cases of submacular hemorrhage that occurred two to four days after anti-VEGF intravitreal injection for occult choroidal neovascularisation in age-related macular degeneration and their management with 25 gauge pars plana vitrectomy with injection of subretinal recombinant tissue plasminogen activator (rTPA) followed by fluid-air exchange and postoperative prone position. Vitrectomy, subretinal rTPA injection and fluid-gas exchange apply as a safe and effective treatment in these cases. Functional results seem to be positive especially if surgical treatment is promptly performed.

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