Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-&alpha; and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats | Zendy

Amal Mansour | Zendy; Bassim M. S. A. Mohamed | Zendy; Sawsan AboulFotouh | Zendy; Eman Abdel-Salam Ibrahim | Zendy; Hannah Shehata | Zendy; Nemat Yassin | Zendy; Wafaa I. ElEraky | Zendy; Ahmed M. Abdel-Tawab | Zendy

Open Access

Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats

Author(s) -

Amal Mansour,

Bassim M. S. A. Mohamed,

Sawsan AboulFotouh,

Eman Abdel-Salam Ibrahim,

Hannah Shehata,

Nemat Yassin,

Wafaa I. ElEraky,

Ahmed M. Abdel-Tawab

Publication year - 2013

Publication title -

neuropsychiatric disease and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.819

H-Index - 67

eISSN - 1178-2021

pISSN - 1176-6328

DOI - 10.2147/ndt.s41020

Subject(s) - pentoxifylline , medicine , endocrinology , imipramine , nitric oxide synthase , hippocampus , enos , tumor necrosis factor alpha , serotonin , nitric oxide , immunostaining , pharmacology , immunohistochemistry , pathology , receptor , alternative medicine

This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (IDO) enzyme, and hence serotonin availability in chronic mild stress (CMS), an animal model of depression.

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