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Decreased white matter integrity before the onset of delusions in patients with Alzheimer's disease: diffusion tensor imaging
Author(s) -
Shutaro Nakaaki,
Sato,
Torii,
Oka,
Negi,
Takashi Nakamae,
Jin Narumoto,
Miyata,
Toshi A. Furukawa,
Mimura
Publication year - 2012
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s38942
Subject(s) - medicine , diffusion mri , white matter , disease , pathology , magnetic resonance imaging , radiology
The pathology of delusions in patients with Alzheimer's disease (AD) associated with white matter (WM) abnormalities is poorly understood. In addition, whether the abnormalities in WM integrity that underlie the delusions develop before the onset of the delusions remains unclear. In this study, we used a diffusion tensor imaging approach to examine the existence of baseline abnormalities in WM integrity in AD patients who developed delusions and AD patients who did not develop delusions.

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