Verbal memory improvement in first-episode psychosis APOE-&epsilon;4 carriers: a pleiotropic effect? | Zendy

Fidel VilaRodriguez | Zendy; Donna J. Lang | Zendy; Heather A. Baitz | Zendy; Kristina M. Gicas | Zendy; Allen E. Thornton | Zendy; Thomas S. Ehmann | Zendy; Geoff Smith | Zendy; Alasdair M. Barr | Zendy; Ivan J. Torres | Zendy; Lili C. Kopala | Zendy; G. William MacEwan | Zendy; Daniel J. Müller | Zendy; James L. Kennedy | Zendy; William G. Honer | Zendy

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Verbal memory improvement in first-episode psychosis <em>APOE-</em>ε4 carriers: a pleiotropic effect?

Author(s) -

Fidel VilaRodriguez,

Donna J. Lang,

Heather A. Baitz,

Kristina M. Gicas,

Allen E. Thornton,

Thomas S. Ehmann,

Geoff Smith,

Alasdair M. Barr,

Ivan J. Torres,

Lili C. Kopala,

G. William MacEwan,

Daniel J. Müller,

James L. Kennedy,

William G. Honer

Publication year - 2017

Publication title -

neuropsychiatric disease and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.819

H-Index - 67

eISSN - 1178-2021

pISSN - 1176-6328

DOI - 10.2147/ndt.s150488

Subject(s) - california verbal learning test , verbal memory , medicine , apolipoprotein e , verbal learning , schizophrenia (object oriented programming) , memory impairment , psychiatry , neuropsychology , clinical psychology , audiology , disease , cognition

Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are -ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of -ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia.

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