Extended-release morphine sulfate in treatment of severe acute and chronic pain | Zendy

Robert Judson Balch | Zendy; Andrea M. Trescot | Zendy

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Extended-release morphine sulfate in treatment of severe acute and chronic pain

Author(s) -

Robert Judson Balch,

Andrea M. Trescot

Publication year - 2010

Publication title -

journal of pain research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 49

ISSN - 1178-7090

DOI - 10.2147/jpr.s6529

Subject(s) - medicine , morphine sulfate , morphine , chronic pain , acute pain , anesthesia , intensive care medicine , pharmacology , physical therapy

Morphine is the archetypal opioid analgesic. Because it is a short-acting opioid, its use has been limited to the management of acute pain. The development of extended-release formulations have resulted in the increased utilization of morphine in chronic pain conditions. This review documents the history of morphine use in pain treatment, and describes the metabolism, pharmacodynamics, formulations, and efficacy of the currently available extended-release morphine medications.

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