Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study | Zendy

Pernille Ravn | Zendy; Mads U. Werner | Zendy; Lona Louring Christrup | Zendy; Erik Lilja Secher | Zendy; Ulrik Skram | Zendy; Trine Therkildsen | Zendy

Open Access

Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

Author(s) -

Pernille Ravn,

Mads U. Werner,

Lona Louring Christrup,

Erik Lilja Secher,

Ulrik Skram,

Trine Therkildsen

Publication year - 2013

Publication title -

journal of pain research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 49

ISSN - 1178-7090

DOI - 10.2147/jpr.s36827

Subject(s) - medicine , buprenorphine , placebo , morphine , crossover study , anesthesia , opioid , analgesic , hyperalgesia , nociception , alternative medicine , receptor , pathology

Opioid therapy is associated with the development of tolerance and paradoxically increased sensitivity to pain. It has been suggested that buprenorphine is associated with a higher antihyperalgesia/analgesia ratio than μ-opioid receptor agonists. The primary outcome of this study was therefore to investigate relative differences in antihyperalgesia and analgesia effects between morphine and buprenorphine in an inflammatory pain model in volunteers. The secondary outcome was to examine the relationship between pain sensitivity and opioid-induced effects on analgesia, antihyperalgesia, and descending pain modulation.

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