A large animal neuropathic pain model in sheep: a strategy for improving the predictability of preclinical models for therapeutic development | Zendy

Denise Wilkes | Zendy; Huang | Zendy; Li | Zendy; Patterson | Zendy; Angeles | Zendy

Open Access

A large animal neuropathic pain model in sheep: a strategy for improving the predictability of preclinical models for therapeutic development

Author(s) -

Denise Wilkes,

Huang,

Li,

Patterson,

Angeles

Publication year - 2012

Publication title -

journal of pain research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 49

ISSN - 1178-7090

DOI - 10.2147/jpr.s34977

Subject(s) - medicine , neuropathic pain , morphine , anesthesia , analgesic , nerve injury , ceiling effect , hindlimb , nociception , sni , pathology , biochemistry , chemistry , alternative medicine , receptor , hydrolysis , acid hydrolysis

Evaluation of analgesics in large animals is a necessary step in the development of better pain medications or gene therapy prior to clinical trials. However, chronic neuropathic pain models in large animals are limited. To address this deficiency, we developed a neuropathic pain model in sheep, which shares many anatomical similarities in spine dimensions and cerebrospinal fluid volume as humans.

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