Pharmacokinetic profile of an intradeltoid diclofenac injection in obese Indian volunteers | Zendy

Vijaya Jaiswal | Zendy; Ojha | Zendy; Patel | Zendy; Nivsarkar | Zendy; Padh | Zendy; Shep | Zendy

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Pharmacokinetic profile of an intradeltoid diclofenac injection in obese Indian volunteers

Author(s) -

Vijaya Jaiswal,

Ojha,

Patel,

Nivsarkar,

Padh,

Shep

Publication year - 2010

Publication title -

journal of pain research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 49

ISSN - 1178-7090

DOI - 10.2147/jpr.s13894

Subject(s) - bioequivalence , pharmacokinetics , bioavailability , diclofenac sodium , diclofenac , medicine , crossover study , chromatography , pharmacology , chemistry , alternative medicine , pathology , placebo

A new propylene glycol-free and reduced-volume formulation of diclofenac sodium 75 mg/mL designed for intradeltoid administration has been found to be bioequivalent to a reference formulation of diclofenac sodium 75 mg/3 mL given via the intragluteal route in normal healthy volunteers. Standard needles may not reach the gluteus maximus muscle in many cases, especially in the obese. The objective of this study was to determine the pharmacokinetic parameters of the new formulation and compare the bioavailability of intradeltoid diclofenac sodium 75 mg/mL with that of the intragluteal 75 mg/3 mL reference formulation in obese volunteers.

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