Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNF&alpha;, TGFB1, and IL-6 | Zendy

Sabine Kersting | Zendy; Reinecke | Zendy; Hilgert | Zendy; Janot | Zendy; Elisabeth Haarmann | Zendy; Albrecht | Zendy; Mueller | Zendy; Herdegen | Zendy; Mittelkoetter | Zendy; Uhl | Zendy; Chromik | Zendy

Open Access

Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6

Author(s) -

Sabine Kersting,

Reinecke,

Hilgert,

Janot,

Elisabeth Haarmann,

Albrecht,

Mueller,

Herdegen,

Mittelkoetter,

Uhl,

Chromik

Publication year - 2013

Publication title -

journal of inflammation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.656

H-Index - 33

ISSN - 1178-7031

DOI - 10.2147/jir.s36415

Subject(s) - tumor necrosis factor alpha , colitis , proinflammatory cytokine , inflammatory bowel disease , immunology , inflammation , knockout mouse , interleukin , medicine , cytokine , receptor , disease

The c-Jun N-terminal kinases (JNKs) are involved in signal transduction of inflammatory bowel diseases. The aim of this study was to examine the function of JNKs by using a low-dose dextran sulfate sodium (DSS) model in JNK1 knockout mice (Mapk8-/-), JNK2 knockout mice (Mapk9-/-), and wild-type controls (WT1, WT2).

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