Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model | Zendy

Weiping Ren | Zendy; Renwen Zhang | Zendy; Bin Wu | Zendy; Paul H. Wooley | Zendy; Monica Hawkins | Zendy

Open Access

Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model

Author(s) -

Weiping Ren,

Renwen Zhang,

Bin Wu,

Paul H. Wooley,

Monica Hawkins

Publication year - 2011

Publication title -

journal of inflammation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.656

H-Index - 33

ISSN - 1178-7031

DOI - 10.2147/jir.s16232

Subject(s) - osteolysis , vascular endothelial growth factor , angiogenesis , calvaria , cancer research , neovascularization , medicine , chemistry , pathology , immunology , surgery , vegf receptors , biochemistry , in vitro

The development of highly vascularized and inflammatory periprosthetic tissue characterizes the progress of aseptic loosening, a major complication of joint arthroplasty. Vascular endothelial growth factor (VEGF) is an important cell signaling protein involved in angiogenesis. The purpose of this study was to investigate whether R2/Fc (a VEGF neutralizing antibody) and SU5416 (a VEGF receptor II [Flk-1] inhibitor) could ameliorate particle-induced inflammatory osteolysis in a mouse model.

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