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Hepatocellular carcinoma (HCC) is the fourth commonest cause of cancer-related mortality; it is associated with various genetic alterations, some involved in metabolic reprogramming. This study aimed to explore the potential metabolic impact of Carbamoyl Phosphate Synthase I ( CPS1 ) and carbamoyl phosphate synthetase/aspartate transcarbamoylase/dihydroorotase (CAD) dysregulation through the reconstruction of a network that integrates information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, Human Metabolome Database (HMDB) and Human Protein Atlas (HPA).

journal of hepatocellular carcinoma

&lt;p&gt;Exploring Metabolic Consequences of&lt;em&gt; CPS1&lt;/em&gt; and&lt;em&gt; CAD&lt;/em&gt; Dysregulation in Hepatocellular Carcinoma by Network Reconstruction&lt;/p&gt;