Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction | Zendy

Ozbil E Dumenci | Zendy; Mei Ran Abellona U | Zendy; Shahid A. Khan | Zendy; Elaine Holmes | Zendy; Simon D. TaylorRobinson | Zendy

Open Access

Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction

Author(s) -

Ozbil E Dumenci,

Mei Ran Abellona U,

Shahid A. Khan,

Elaine Holmes,

Simon D. TaylorRobinson

Publication year - 2020

Publication title -

journal of hepatocellular carcinoma

Language(s) - English

Resource type - Journals

ISSN - 2253-5969

DOI - 10.2147/jhc.s239039

Subject(s) - kegg , pyrimidine metabolism , biology , metabolic pathway , metabolic network , hepatocellular carcinoma , gene , urea cycle , downregulation and upregulation , computational biology , transcriptome , biochemistry , cancer research , gene expression , enzyme , amino acid , arginine , purine

Hepatocellular carcinoma (HCC) is the fourth commonest cause of cancer-related mortality; it is associated with various genetic alterations, some involved in metabolic reprogramming. This study aimed to explore the potential metabolic impact of Carbamoyl Phosphate Synthase I ( CPS1 ) and carbamoyl phosphate synthetase/aspartate transcarbamoylase/dihydroorotase (CAD) dysregulation through the reconstruction of a network that integrates information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, Human Metabolome Database (HMDB) and Human Protein Atlas (HPA).

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