Reconstruction is not renovation &ndash; the role of remodeling in asthma | Zendy

Markus Weckmann | Zendy; Brian G. Oliver | Zendy; Thomas Trian | Zendy

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Reconstruction is not renovation – the role of remodeling in asthma

Author(s) -

Markus Weckmann,

Brian G. Oliver,

Thomas Trian

Publication year - 2009

Publication title -

journal of asthma and allergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.162

H-Index - 30

ISSN - 1178-6965

DOI - 10.2147/jaa.s4016

Subject(s) - medicine , extracellular matrix , asthma , pathological , angiogenesis , phenotype , tissue remodeling , bioinformatics , pathology , immunology , inflammation , microbiology and biotechnology , biology , biochemistry , gene

The chronicity of asthma results not only in persistent lung inflammation but also in changes in structure and composition of this vital organ. These changes are most commonly referred to as remodeling, and include epithelial dysplasia, angiogenesis, changes in the extracellular matrix and increased smooth muscle mass. In this review we summarize recent findings on the contribution of remodeling to the pathological phenotype of asthma. We discuss how and why current treatment (such as corticosteroids) options fail to adequately treat remodeling.

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