Morning and evening efficacy evaluation of rupatadine (10 and 20 mg), compared with cetirizine 10 mg in perennial allergic rhinitis: a randomized, double-blind, placebo-controlled trial | Zendy

Iñaki Izquierdo | Zendy; Giralt | Zendy

Open Access

Morning and evening efficacy evaluation of rupatadine (10 and 20 mg), compared with cetirizine 10 mg in perennial allergic rhinitis: a randomized, double-blind, placebo-controlled trial

Author(s) -

Iñaki Izquierdo,

Giralt

Publication year - 2011

Publication title -

journal of asthma and allergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.162

H-Index - 30

ISSN - 1178-6965

DOI - 10.2147/jaa.s18265

Subject(s) - medicine , cetirizine , evening , morning , double blind , placebo , randomized controlled trial , anesthesia , alternative medicine , pathology , astronomy , physics

A circadian rhythm of symptoms has been reported in allergic rhinitis (AR). Severity of all major symptoms of AR, including runny nose, sneezing, and nasal congestion, is typically at its peak in the morning. The objective of this study was to explore the efficacy of the antihistamine and platelet activating factor (PAF) antagonist rupatadine in the morning and evening and to evaluate whether rupatadine provides effective symptom relief throughout the 24-hour dosing interval.

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