Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells | Zendy

mingfang Shen | Zendy; Baoan Chen | Zendy; Jian Cheng | Zendy; Feng Gao | Zendy; Wenlin Xu | Zendy; Hui-lin Shen | Zendy; Jia-Hua Ding | Zendy; Chong Gao | Zendy; Qian Sun | Zendy; Xinchen Sun | Zendy; Hongyan Cheng | Zendy; Guohong Li | Zendy; Wenji Chen | Zendy; Ning-Na Chen | Zendy; Lijie Liu | Zendy; Xiaomao Li | Zendy; Xuemei Wang | Zendy

Open Access

Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells

Author(s) -

mingfang Shen,

Baoan Chen,

Jian Cheng,

Feng Gao,

Wenlin Xu,

Hui-lin Shen,

Jia-Hua Ding,

Chong Gao,

Qian Sun,

Xinchen Sun,

Hongyan Cheng,

Guohong Li,

Wenji Chen,

Ning-Na Chen,

Lijie Liu,

Xiaomao Li,

Xuemei Wang

Publication year - 2009

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s5036

Subject(s) - daunorubicin , apoptosis , multiple drug resistance , k562 cells , in vitro , cytotoxic t cell , cancer research , leukemia , caspase 3 , cytotoxicity , pharmacology , chemistry , programmed cell death , drug resistance , biology , immunology , biochemistry , microbiology and biotechnology

Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe3O4 (MNP(Fe3O4)) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe3O4) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe3O4) and BrTet combination on CML.

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