Tunable drug loading and release from polypeptide multilayer nanofilms | Zendy

Bingyun Li | Zendy

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Tunable drug loading and release from polypeptide multilayer nanofilms

Author(s) -

Bingyun Li

Publication year - 2009

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s4970

Subject(s) - drug , cefazolin , gentamicin , materials science , methylene blue , drug delivery , drug carrier , biophysics , biomedical engineering , nanotechnology , chemistry , antibiotics , pharmacology , medicine , organic chemistry , biochemistry , catalysis , photocatalysis , biology

Polypeptide multilayer nanofilms were prepared using electrostatic layer-by-layer self-assembly nanotechnology. Small charged drug molecules (eg, cefazolin, gentamicin, and methylene blue) were loaded in polypeptide multilayer nanofilms. Their loading and release were found to be pH-dependent and could also be controlled by changing the number of film layers and drug incubation time, and applying heat-treatment after film formation. Antibioticloaded polypeptide multilayer nanofilms showed controllable antibacterial properties against Staphylococcus aureus. The developed biodegradable polypeptide multilayer nanofilms are capable of loading both positively- and negatively-charged drug molecules and promise to serve as drug delivery systems on biomedical devices for preventing biomedical device-associated infection, which is a significant clinical complication for both civilian and military patients.

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