Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly (lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway | Zendy

Chia Cheng Hou | Zendy; TsungLin Tsai | Zendy; Wen Pin Su | Zendy; Hsing Pang Hsieh | Zendy; Chen-Sheng Yeh | Zendy; Dar Bin Shieh | Zendy; WuChou Su | Zendy

Open Access

Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly (lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway

Author(s) -

Chia Cheng Hou,

TsungLin Tsai,

Wen Pin Su,

Hsing Pang Hsieh,

Chen-Sheng Yeh,

Dar Bin Shieh,

WuChou Su

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s47208

Subject(s) - endoplasmic reticulum , in vivo , mtt assay , viability assay , plga , confocal microscopy , glycolic acid , blot , pulmonary surfactant , unfolded protein response , intracellular , chemistry , biophysics , cell , lactic acid , microbiology and biotechnology , biochemistry , in vitro , biology , genetics , bacteria , gene

Y294002 (LY) is a potent inhibitor of phosphatidylinositol 3-kinases (PI3Ks); however, biological applications of LY are limited by its poor solubility and pharmacokinetic profile. This study aimed at developing LY-loaded surfactant-free poly(lactic-co-glycolic acid) (PLGA) nanoparticles (SF-LY NPs) to improve the therapeutic efficacy of LY.

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