Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4 | Zendy

Akihiro Matsukawa | Zendy; Shiozaki | Zendy; Kitajima | Zendy; Mazaki | Zendy; Yoshida | Zendy; Masato Tanaka | Zendy; Umezawa | Zendy; Nakamura | Zendy; Yoshihiro Ito | Zendy; Ozaki | Zendy

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Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4

Author(s) -

Akihiro Matsukawa,

Shiozaki,

Kitajima,

Mazaki,

Yoshida,

Masato Tanaka,

Umezawa,

Nakamura,

Yoshihiro Ito,

Ozaki

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s44124

Subject(s) - nanocarriers , in vivo , bone morphogenetic protein 2 , bone morphogenetic protein , materials science , biomedical engineering , nanotechnology , microbiology and biotechnology , chemistry , medicine , drug delivery , in vitro , biology , biochemistry , gene

Bone defects and nonunions are major clinical skeletal problems. Growth factors are commonly used to promote bone regeneration; however, the clinical impact is limited because the factors do not last long at a given site. The introduction of tissue engineering aimed to deter the diffusion of these factors is a promising therapeutic strategy. The purpose of the present study was to evaluate the in vivo osteogenic capability of an engineered bone morphogenetic protein-4 (BMP4) fusion protein.

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