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Intravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrier-based formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics.

international journal of nanomedicine

Nanoemulsion loaded with lycobetaine&amp;ndash;oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity