Nanoemulsion loaded with lycobetaine&ndash;oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity | Zendy

Hui Zhao | Zendy; Lü | Zendy; Tao Gong | Zendy; Zhirong Zhang | Zendy

Open Access

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

Author(s) -

Hui Zhao,

Lü,

Tao Gong,

Zhirong Zhang

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s43892

Subject(s) - in vivo , chemistry , pharmacology , peg ratio , pharmacokinetics , oleic acid , nanocarriers , bioavailability , medicine , biochemistry , drug , biology , finance , economics , microbiology and biotechnology

Intravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrier-based formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics.

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