Enhancing the bioactivity of Poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model | Zendy

Dexin Wang | Zendy; Yao He | Zendy; Guoan Bi | Zendy; Qu | Zendy; Jiwei Zou | Zendy; Pan | Zendy; Junjun Fan | Zendy; Chen | Zendy; Dong | Zendy; Liu | Zendy; Guoxian Pei | Zendy; Jiandong Ding | Zendy

Open Access

Enhancing the bioactivity of Poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model

Author(s) -

Dexin Wang,

Yao He,

Guoan Bi,

Qu,

Jiwei Zou,

Pan,

Junjun Fan,

Chen,

Dong,

Liu,

Guoxian Pei,

Jiandong Ding

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s43706

Subject(s) - glycolic acid , materials science , scaffold , coating , biomedical engineering , nano , lactic acid , rabbit (cipher) , chemical engineering , bone healing , nanotechnology , composite material , medicine , surgery , genetics , bacteria , biology , statistics , mathematics , engineering

Poly(lactic-co-glycolic acid) (PLGA) is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA) was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keeping the polyester skeleton of the scaffolds.

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