Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer | Zendy

HuLin Jiang | Zendy; You-Kyoung Kim | Zendy; Arash MinaiTehrani | Zendy; Lee | Zendy; Chong-Su Cho | Zendy; MyungHaing Cho | Zendy

Open Access

Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer

Author(s) -

HuLin Jiang,

You-Kyoung Kim,

Arash MinaiTehrani,

Lee,

Chong-Su Cho,

MyungHaing Cho

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s42949

Subject(s) - polyethylenimine , ethylene glycol , chitosan , transfection , peg ratio , gene delivery , folate receptor , chemistry , cationic polymerization , amine gas treating , cancer cell , materials science , biochemistry , cancer , polymer chemistry , biology , organic chemistry , gene , genetics , finance , economics

Chitosan and chitosan derivatives have been proposed as alternative and biocompatible cationic polymers for nonviral gene delivery. However, the low transfection efficiency and low specificity of chitosan is an aspect of this approach that must be addressed prior to any clinical application. In the present study, folated poly(ethylene glycol)-chitosan-graft-polyethylenimine (FPCP) was investigated as a potential folate receptor-overexpressed cancer cell targeting gene carrier.

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