Liposomes functionalized to overcome the blood&ndash;brain barrier and to target amyloid-&beta; peptide: the chemical design affects the permeability across an in vitro model | Zendy

Francesca Re | Zendy; Salvati | Zendy; Sesana | Zendy; Cambianica | Zendy; Giulio Sancini | Zendy; Masserini | Zendy; Gregori | Zendy

Open Access

Liposomes functionalized to overcome the blood–brain barrier and to target amyloid-β peptide: the chemical design affects the permeability across an in vitro model

Author(s) -

Francesca Re,

Salvati,

Sesana,

Cambianica,

Giulio Sancini,

Masserini,

Gregori

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s42783

Subject(s) - liposome , biophysics , phosphatidic acid , transferrin , chemistry , transferrin receptor , biochemistry , blood–brain barrier , biology , membrane , phospholipid , neuroscience , central nervous system

We investigated the ability of amyloid-β-targeting liposomes, decorated with an anti-transferrin receptor antibody, to cross the blood-brain barrier (BBB), comparing two antibody ligation techniques.

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