Nano-BaSO4: a novel antimicrobial additive to pellethane | Zendy

Thomas J. Webster | Zendy; David Stout | Zendy; George E. Aninwene | Zendy; Yang Yang | Zendy

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Nano-BaSO4: a novel antimicrobial additive to pellethane

Author(s) -

Thomas J. Webster,

David Stout,

George E. Aninwene,

Yang Yang

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s40300

Subject(s) - antimicrobial , materials science , barium sulfate , staphylococcus aureus , biomedical engineering , microbiology and biotechnology , bacteria , medicine , biology , genetics , metallurgy

Hospital-acquired infections remain a costly clinical problem. Barium sulfate (BaSO4, in micron particulate form) is a common radiopacifying agent that is added to catheters and endotracheal tubes. Due to the recently observed ability of nanostructured surface features to decrease functions of bacteria without the aid of antibiotics, the objective of this in vitro study was to incorporate nano-barium sulfate into pellethane and determine the antimicrobial properties of the resulting composites. The results demonstrated for the first time that the incorporation of nano-barium sulfate into pellethane enhanced antimicrobial properties (using Staphylococcus aureus and Pseudomonas aeruginosa) compared to currently used pellethane; properties that warrant further investigation for a wide range of clinical applications.

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