Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation | Zendy

Young Wook Choi | Zendy; Kang | Zendy; Park | Zendy

Open Access

Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation

Author(s) -

Young Wook Choi,

Kang,

Park

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s39491

Subject(s) - nanocarriers , liposome , folate receptor , chemistry , peptide , drug delivery , internalization , biophysics , vesicle , in vitro , drug carrier , biochemistry , receptor , cancer cell , biology , membrane , cancer , organic chemistry , genetics

A novel dual ligand-modified liposome, folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier (FP-Lipo), was designed to overcome the nonselectivity of conventional penetrating peptide-tagged nanoparticulates and to provide the advantage of selective targeting of the folic acid receptor, which is frequently overexpressed on epithelial cancer cells.

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