Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic | Zendy

Jong-Sang Park | Zendy;  An | Zendy; Nam | Zendy; Choi | Zendy; Bai | Zendy; Yan Lee | Zendy

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Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic

Author(s) -

Jong-Sang Park,

 An,

Nam,

Choi,

Bai,

Yan Lee

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s39072

Subject(s) - dapi , tunel assay , microbiology and biotechnology , transfection , terminal deoxynucleotidyl transferase , in vivo , genetic enhancement , apoptosis , biology , cancer research , chemistry , gene , biochemistry

Glioma is still one of the most complicated forms of brain tumor to remove completely due to its location and the lack of an efficient means to specifically eliminate tumor cells. For these reasons, this study has examined the effectiveness of a nonviral gene therapy approach utilizing a tumor-selective killer gene on a brain tumor xenograft model.

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