Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models | Zendy

Zhizhi Sun | Zendy; Yathindranath | Zendy; Matthew Worden | Zendy; Thliveris | Zendy; Chu | Zendy; Parkinson | Zendy; Hegmann | Zendy; Don Miller | Zendy

Open Access

Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models

Author(s) -

Zhizhi Sun,

Yathindranath,

Matthew Worden,

Thliveris,

Chu,

Parkinson,

Hegmann,

Don Miller

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s39048

Subject(s) - viability assay , iron oxide nanoparticles , chemistry , cytotoxicity , biophysics , biocompatibility , mtt assay , toxicity , pharmacology , biochemistry , cell , iron oxide , in vitro , biology , organic chemistry

Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.

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