Codelivery of zoledronic acid and double-stranded RNA from core-shell nanoparticles | Zendy

Weili Yan | Zendy; Ding | Zendy; Chen | Zendy; Wang | Zendy; Liu | Zendy; Babu | Zendy; William R. Ravis | Zendy

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Codelivery of zoledronic acid and double-stranded RNA from core-shell nanoparticles

Author(s) -

Weili Yan,

Ding,

Chen,

Wang,

Liu,

Babu,

William R. Ravis

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s38928

Subject(s) - zoledronic acid , cytotoxicity , chemistry , materials science , in vitro , nuclear chemistry , biochemistry , medicine , surgery

Zoledronic acid, an inhibitor of osteoclast-mediated bone resorption, has been shown to have both direct and indirect antitumor activity. However, its use in extraskeletal malignancy is limited due to rapid uptake and accumulation within bone. Polyinosinic acid-polycytidylic acid [poly (I:C)] is a synthetic double-stranded RNA with direct antitumor cytotoxicity if it can be delivered to tumor cells intracellularly.

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