Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo | Zendy

Yingying Shen | Zendy; Yuanzhi Shao | Zendy; Haoqiang He | Zendy; Yunpu Tan | Zendy; Xiumei Tian | Zendy; Fukang Xie | Zendy; Li Li | Zendy

Open Access

Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Author(s) -

Yingying Shen,

Yuanzhi Shao,

Haoqiang He,

Yunpu Tan,

Xiumei Tian,

Fukang Xie,

Li Li

Publication year - 2013

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s38213

Subject(s) - in vivo , neural stem cell , mesoporous silica , mesenchymal stem cell , materials science , stem cell , gadolinium , magnetic resonance imaging , nanoparticle , mesoporous material , neurosphere , biophysics , nanotechnology , biomedical engineering , in vitro , chemistry , microbiology and biotechnology , adult stem cell , biology , biochemistry , endothelial stem cell , medicine , radiology , metallurgy , catalysis

We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd(2)O(3)@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd(2)O(3) clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd(2)O(3)@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.

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