Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica | Zendy

Chuanbin Wu | Zendy; Wang | Zendy; Bao Chen | Zendy; Quan Quan | Zendy; Li | Zendy; Wu | Zendy; Dian | Zendy; Dong Dong | Zendy

Open Access

Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

Author(s) -

Chuanbin Wu,

Wang,

Bao Chen,

Quan Quan,

Li,

Wu,

Dian,

Dong Dong

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s37650

Subject(s) - pellets , angle of repose , mesoporous silica , materials science , bioavailability , differential scanning calorimetry , adsorption , chemical engineering , contact angle , mesoporous material , wetting , dissolution , scanning electron microscope , carbamazepine , extrusion , nuclear chemistry , chromatography , chemistry , organic chemistry , composite material , pharmacology , medicine , physics , epilepsy , engineering , thermodynamics , catalysis , neuroscience , biology

The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly water-soluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by extrusion/spheronization into pellets. Physicochemical characterization of the preparation was carried out by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption, small-angle and wide-angle x-ray diffraction, and differential scanning calorimetry. Flowability and wettability of the drug-loaded silica powder were evaluated by bulk and tapped density and by the angle of repose and contact angle, respectively. The drug-loaded silica powder was formulated into pellets to improve flowability.

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