Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle | Zendy

JyhPing Chen | Zendy; Peggy Yang | Zendy; YuJen Lu | Zendy; YunnHwa Ma | Zendy; ShuJu Tu | Zendy

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Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Author(s) -

JyhPing Chen,

Peggy Yang,

YuJen Lu,

YunnHwa Ma,

ShuJu Tu

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s36197

Subject(s) - nanocarriers , materials science , biocompatibility , nuclear chemistry , thermogravimetric analysis , superparamagnetism , tissue plasminogen activator , drug delivery , surface modification , chemistry , nanotechnology , organic chemistry , biochemistry , magnetization , physics , quantum mechanics , magnetic field , metallurgy

Silica-coated magnetic nanoparticle (SiO(2)-MNP) prepared by the sol-gel method was studied as a nanocarrier for targeted delivery of tissue plasminogen activator (tPA). The nanocarrier consists of a superparamagnetic iron oxide core and an SiO(2) shell and is characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, superconducting quantum interference device, and thermogravimetric analysis. An amine-terminated surface silanizing agent (3-aminopropyltrimethoxysilane) was used to functionalize the SiO(2) surface, which provides abundant -NH(2) functional groups for conjugating with tPA.

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