Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury | Zendy

Xinwu Lu | Zendy; Jinbaoqin | Zendy; Zhang | Zendy; Li | Zendy; Xie Xie | Zendy; Ye | Zendy; Jiang | Zendy; Lin | Zendy

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Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury

Author(s) -

Xinwu Lu,

Jinbaoqin,

Zhang,

Li,

Xie Xie,

Ye,

Jiang,

Lin

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s35647

Subject(s) - stem cell , medicine , transplantation , magnetic resonance imaging , adipose tissue , homing (biology) , cell therapy , pathology , radiology , biology , microbiology and biotechnology , ecology

Stem cell therapy has shown great promise for regenerative repair of injured or diseased tissues. Adipose-derived stem cells (ADSCs) have become increasingly attractive candidates for cellular therapy. Magnetic resonance imaging has been proven to be effective in tracking magnetic-labeled cells and evaluating their clinical relevance after cell transplantation. This study investigated the feasibility of imaging green fluorescent protein-expressing ADSCs (GFP-ADSCs) labeled with superparamagnetic iron oxide particles, and tracked them in vivo with noninvasive magnetic resonance imaging after cell transplantation in a model of mouse carotid artery injury.

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