Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid) | Zendy

Tingli Lu | Zendy; Tao Chen | Zendy; Wang | Zendy; Yufan Ma | Zendy; Zhang | Zendy

Open Access

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Author(s) -

Tingli Lu,

Tao Chen,

Wang,

Yufan Ma,

Zhang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s35576

Subject(s) - calcein , liposome , vesicle , phosphatidylcholine , polymer , chemistry , surface charge , chromatography , synthetic membrane , membrane , phospholipid , biophysics , analytical chemistry (journal) , biochemistry , organic chemistry , biology

Liposomes containing pH-sensitive polymers are promising candidates for the treatment of tumors and localized infection. This study aimed to identify parameters influencing the extent of contents release from poly(ethylacrylic acid) (PEAA) vesicles, focusing on the effects of polymer size, lipid composition, vesicle surface charge, and temperature.

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