Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method
Author(s) -
Weien Yuan,
Guang Liu,
Xiaoyun Hong,
Mier Jiang
Publication year - 2012
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s33993
Subject(s) - emulsion , microsphere , materials science , chromatography , chemistry , chemical engineering , organic chemistry , engineering
The main treatments for cancers are still chemotherapy and radiotherapy for intermediate-stage cancer and terminal cancer. However, the therapeutic methods often result in a decreased neutrophilic granulocyte count and other side effects. In this study, in order to improve the neutrophilic granulocyte levels in the blood after radiotherapy and chemotherapy, we developed a sustained-release granulocyte colony-stimulating factor (G-CSF) microsphere formulation using a novel solid-in-oil-in-oil-in-water (S/O/O/W) emulsification method.
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