Open AccessLactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma
Author(s) -
Robert J Lee,
Zhang,
Yung,
Li,
Xiaoju Zhou,
L. Lee
Publication year - 2012
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s33965
Subject(s) - calcein , asialoglycoprotein receptor , doxorubicin , liposome , cytotoxicity , pharmacokinetics , chemistry , drug delivery , mtt assay , pharmacology , biodistribution , in vitro , biochemistry , hepatocyte , biology , chemotherapy , membrane , organic chemistry , genetics
N-lactosyl-dioleoylphosphatidylethanolamine (Lac-DOPE) was synthesized and evaluated as a liver-specific targeting ligand via asialoglycoprotein receptors for liposomal delivery of doxorubicin.
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