Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study | Zendy

Tao Gong | Zendy; Jiang | Zendy; Ren | Zendy; Xun Sun | Zendy; Qiang Zhang | Zendy; Xu Song | Zendy; Zhirongzhang | Zendy

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Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study

Author(s) -

Tao Gong,

Jiang,

Ren,

Xun Sun,

Qiang Zhang,

Xu Song,

Zhirongzhang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s33228

Subject(s) - nimodipine , pharmacokinetics , irritability , bioavailability , micelle , compatibility (geochemistry) , pharmacology , materials science , medicine , chemistry , calcium , organic chemistry , menopause , composite material , aqueous solution , metallurgy

The clinical application of nimodipine (NIM) is limited by several unfavorable properties, which are induced by its low aqueous solubility. In the present study, nimodipine-loaded egg phosphatidylcholine-sodium glycocholate mixed micelles (NIM-EPC-SGC-MMs) were prepared to improve the water solubility of NIM, thus allowing it to be more applicable for clinical use.

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