Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity | Zendy

TongRong Jan | Zendy; Shen | Zendy; Liang | Zendy; ChiaChi Wang | Zendy; Liao | Zendy

Open Access

Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity

Author(s) -

TongRong Jan,

Shen,

Liang,

ChiaChi Wang,

Liao

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s31054

Subject(s) - immunity , cell mediated immunity , immunology , nanoparticle , iron oxide nanoparticles , immune system , materials science , chemistry , medicine , nanotechnology

It was recently reported that iron oxide nanoparticles attenuated antigen-specific humoral responses and T cell cytokine expression in ovalbumin-sensitized mice. It is presently unclear whether iron oxide nanoparticles influence T helper 1 cell-mediated immunity. The present study aimed to investigate the effect of iron oxide nanoparticles on delayed-type hypersensitivity (DTH), whose pathophysiology requires the participation of T helper 1 cells and macrophages.

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