Open AccessControlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
Author(s) -
Weien Yuan,
Xinxin Yang,
Ruiyuan Zheng,
Yunpeng Cai,
Meiling Liao,
Zhenguo Liu
Publication year - 2012
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s30463
Subject(s) - benserazide , dyskinesia , levodopa , pharmacology , medicine , apomorphine , chemistry , anesthesia , parkinson's disease , agonist , receptor , disease
Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood.
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