Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11 | Zendy

Camila I. de Oliveira | Zendy; Diego Santos | Zendy; Carneiro | Zendy; D.F. Moura | Zendy; Fukutani | Zendy; Jorge Clarêncio | Zendy; Soto | Zendy; Socorro Espuelas | Zendy; Brodskyn | Zendy; Aldina Barral | Zendy; Manoel BarralNetto | Zendy

Open Access

Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11

Author(s) -

Camila I. de Oliveira,

Diego Santos,

Carneiro,

D.F. Moura,

Fukutani,

Jorge Clarêncio,

Soto,

Socorro Espuelas,

Brodskyn,

Aldina Barral,

Manoel BarralNetto

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s30093

Subject(s) - plga , leishmaniasis , nanoparticle , immunization , materials science , nanotechnology , membrane , chemistry , medicine , immunology , immune system , biochemistry

Vaccine development has been a priority in the fight against leishmaniases, which are vector-borne diseases caused by Leishmania protozoa. Among the different immunization strategies employed to date is inoculation of plasmid DNA coding for parasite antigens, which has a demonstrated ability to induce humoral and cellular immune responses. In this sense, inoculation of plasmid DNA encoding Leishmania kinetoplasmid membrane protein-11 (KMP-11) was able to confer protection against visceral leishmaniasis. However, recently the use of antigen delivery systems such as poly(lactic-co-glycolic acid) (PLGA) nanoparticles has also proven effective for eliciting protective immune responses.

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