A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1 | Zendy

Qiang Zhang | Zendy; Qu | Zendy; Lars Hovgaard | Zendy; Jiancheng Wang | Zendy; Xuan Zhang | Zendy

Open Access

A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1

Author(s) -

Qiang Zhang,

Qu,

Lars Hovgaard,

Jiancheng Wang,

Xuan Zhang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s30013

Subject(s) - incretin , glucagon like peptide 1 , peptide , chemistry , hormone , absorption (acoustics) , medicine , endocrinology , biochemistry , materials science , diabetes mellitus , type 2 diabetes , composite material

Glucagon-like peptide-1 (GLP-1) (7-36) is a peptide incretin hormone released from the endocrine L-cells of the intestinal mucosa with unique antidiabetic potential. Due to low absorption efficiency and instability in the gastrointestinal tract, the introduction of orally active GLP-1 is a large challenge. Here we developed a novel silica-based pH-sensitive nanomatrix of GLP-1 (SPN-GLP-1) in order to provide a strategy for oral peptide delivery.

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