Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model | Zendy

Yongping Li | Zendy; Zhanrong Li | Zendy; Wu | Zendy; Jingguo Li | Zendy; Yao Yao | Zendy; Zhang | Zendy; Wenxin Zhang | Zendy; Sun | Zendy; Shi Shi | Zendy; Dan Liang | Zendy

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Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model

Author(s) -

Yongping Li,

Zhanrong Li,

Wu,

Jingguo Li,

Yao Yao,

Zhang,

Wenxin Zhang,

Sun,

Shi Shi,

Dan Liang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s29945

Subject(s) - celastrol , retinoblastoma , cancer research , nanoparticle , medicine , pharmacology , chemistry , materials science , nanotechnology , apoptosis , biochemistry , gene

Celastrol, a Chinese herbal medicine, has shown antitumor activity against various tumor cell lines. However, the effect of celastrol on retinoblastoma has not yet been analyzed. Additionally, the poor water solubility of celastrol restricts further therapeutic applications. The goal of this study was to evaluate the effect of celastrol nanoparticles (CNPs) on retinoblastoma and to investigate the potential mechanisms involved.

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