Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytes | Zendy

Salik Hussain | Zendy; Al-Nsour | Zendy; Rice | Zendy; Marshburn | Zendy; Ji | Zendy; Zink | Zendy; Ying-ling | Zendy; Nigel J. Walker | Zendy; Stavros Garantziotis | Zendy

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Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytes

Author(s) -

Salik Hussain,

Al-Nsour,

Rice,

Marshburn,

Ji,

Zink,

Ying-ling,

Nigel J. Walker,

Stavros Garantziotis

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s29429

Subject(s) - cd14 , lipopolysaccharide , cytokine , nanoparticle , materials science , biophysics , tumor necrosis factor alpha , monocyte , interferon gamma , chemistry , nanotechnology , immunology , medicine , biology , immune system

Cerium dioxide (CeO(2)) nanoparticles have potential therapeutic applications and are widely used for industrial purposes. However, the effects of these nanoparticles on primary human cells are largely unknown. The ability of nanoparticles to exacerbate pre-existing inflammatory disorders is not well documented for engineered nanoparticles, and is certainly lacking for CeO(2) nanoparticles. We investigated the inflammation-modulating effects of CeO(2) nanoparticles at noncytotoxic concentrations in human peripheral blood monocytes.

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