Open AccessImproving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide
Author(s) -
JyhPing Chen,
YuJen Lu,
ShengChe Hung,
KuoChen Wei
Publication year - 2012
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s29376
Subject(s) - nanocarriers , polyacrylic acid , materials science , thermal stability , nuclear chemistry , nanotechnology , chemical engineering , chemistry , drug delivery , organic chemistry , polymer , engineering
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a commercial chemotherapeutic drug for treating malignant brain tumors, has poor thermal stability and a short half-life. Immobilization of BCNU on a nanocarrier might increase the thermal stability of BCNU and extend its half-life.
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