Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance | Zendy

Baoan Chen | Zendy; Yanyan Ren | Zendy

Open Access

Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance

Author(s) -

Baoan Chen,

Yanyan Ren

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s29357

Subject(s) - daunorubicin , multiple drug resistance , hyperthermia , apoptosis , in vivo , magnetic hyperthermia , cancer research , chemotherapy , p glycoprotein , materials science , magnetic nanoparticles , in vitro , caspase 3 , pharmacology , medicine , nanoparticle , chemistry , drug resistance , programmed cell death , biology , nanotechnology , biochemistry , microbiology and biotechnology

Multidrug resistance in cancer is a major obstacle for clinical therapeutics, and is the reason for 90% of treatment failures. This study investigated the efficiency of novel multifunctional Fe(3)O(4) magnetic nanoparticles (Fe(3)O(4)-MNP) combined with chemotherapy and hyperthermia for overcoming multidrug resistance in an in vivo model of leukemia.

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