Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance | Zendy

Cristina Riggio | Zendy; M. Pilar Calatayud | Zendy; Clare Hoskins | Zendy; Josephine Pinkernelle | Zendy; Beatriz Sanz | Zendy; Teobaldo E. Torres | Zendy; M. R. Ibarra | Zendy; Lijun Wang | Zendy; Gerburg Keilhoff | Zendy; Gerardo F. Goya | Zendy; Vittoria Raffa | Zendy; A. Cuschieri | Zendy

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Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance

Author(s) -

Cristina Riggio,

M. Pilar Calatayud,

Clare Hoskins,

Josephine Pinkernelle,

Beatriz Sanz,

Teobaldo E. Torres,

M. R. Ibarra,

Lijun Wang,

Gerburg Keilhoff,

Gerardo F. Goya,

Vittoria Raffa,

A. Cuschieri

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s28460

Subject(s) - nanoparticle , nanotechnology , magnetic nanoparticles , humanities , intracellular , materials science , physics , chemistry , art , biochemistry

It has been proposed in the literature that Fe(3)O(4) magnetic nanoparticles (MNPs) could be exploited to enhance or accelerate nerve regeneration and to provide guidance for regenerating axons. MNPs could create mechanical tension that stimulates the growth and elongation of axons. Particles suitable for this purpose should possess (1) high saturation magnetization, (2) a negligible cytotoxic profile, and (3) a high capacity to magnetize mammalian cells. Unfortunately, the materials currently available on the market do not satisfy these criteria; therefore, this work attempts to overcome these deficiencies.

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