Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve | Zendy

Ya Zhang | Zendy; Weikai Zhang | Zendy; J R Johnston | Zendy; Tracey A. Newman | Zendy; Ilmari Pyykkö | Zendy

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Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

Author(s) -

Ya Zhang,

Weikai Zhang,

J R Johnston,

Tracey A. Newman,

Ilmari Pyykkö

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s28185

Subject(s) - polymersome , spiral ganglion , peptide , round window , drug delivery , inner ear , amphiphile , medicine , biophysics , chemistry , materials science , nanotechnology , anatomy , biochemistry , copolymer , biology , organic chemistry , polymer

Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin receptor on neurons and was expected to target the polymersomes toward the cochlear nerve. The Tet1 functionalized PEG-b-PCL polymersomes were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.

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