Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan&ndash;folic acid micelles | Zendy

Dianrui Zhang | Zendy; Wang | Zendy

Open Access

Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles

Author(s) -

Dianrui Zhang,

Wang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27823

Subject(s) - micelle , paclitaxel , folate receptor , endocytosis , deoxycholic acid , cytotoxicity , internalization , drug delivery , cancer cell , chemistry , targeted drug delivery , chitosan , pharmacology , in vitro , cell culture , cell , biochemistry , cancer , bile acid , biology , medicine , organic chemistry , genetics , aqueous solution

A critical disadvantage for successful chemotherapy with paclitaxel (PTX) is its nontargeting nature to cancer cells. Folic acid has been employed as a targeting ligand of various anticancer agents to increase their cellular uptake within target cells since the folate receptor is overexpressed on the surface of such tumor cells. In this study, a novel biodegradable deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugate (DOMC-FA) was used to form micelles for encapsulating the anticancer drug PTX.

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