Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method | Zendy

Rassoul Dinarvand | Zendy; Tahereh Sadat Jafarzadeh Kashi | Zendy; Eskandarion | Zendy; Mehdi EsfandyariManesh | Zendy; Nasrin Samadi | Zendy; Fatemeh Atyabi | Zendy; Eshraghi | Zendy

Open Access

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Author(s) -

Rassoul Dinarvand,

Tahereh Sadat Jafarzadeh Kashi,

Eskandarion,

Mehdi EsfandyariManesh,

Nasrin Samadi,

Fatemeh Atyabi,

Eshraghi

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27709

Subject(s) - minocycline , plga , materials science , nanoparticle , drug , antibacterial activity , pairing , drug delivery , chemical engineering , nanotechnology , chemistry , antibiotics , pharmacology , medicine , bacteria , biochemistry , engineering , superconductivity , physics , quantum mechanics , biology , genetics

Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections.

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