Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity | Zendy

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Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity

Author(s) -

Ho,

Sánchez,

Shahangian,

Al-Shyoukh,

Cheng

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27540

Subject(s) - drug , ribavirin , antiviral drug , herpes simplex virus , pharmacology , toxicity , drug discovery , virus , medicine , biology , virology , bioinformatics , hepatitis c virus

Infectious diseases cause many molecular assemblies and pathways within cellular signaling networks to function aberrantly. The most effective way to treat complex, diseased cellular networks is to apply multiple drugs that attack the problem from many fronts. However, determining the optimal combination of several drugs at specific dosages to reach an endpoint objective is a daunting task.

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