Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus | Zendy

Xun Sun | Zendy; Han Han | Zendy; Zhao | Zendy; Tao Gong | Zendy; Zhi-RongZhang | Zendy

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Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus

Author(s) -

Xun Sun,

Han Han,

Zhao,

Tao Gong,

Zhi-RongZhang

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27526

Subject(s) - adenoviridae , microbiology and biotechnology , transfection , gene delivery , cytotoxicity , genetic enhancement , chemistry , cell culture , in vitro , biology , biochemistry , gene , genetics

The generation of anti-adenovirus neutralizing antibody (NAb) in humans severely restricts the utilization of recombinant adenovirus serotype 5 (Ad5) vectors in gene therapy for a wide range of clinical trials. To overcome this limitation, we ionically complexed Ad5 with a newly synthesized copolymer, which we called APC, making an adenovirus shielded from NAb.

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