Synergetic effects of doxycycline-loaded chitosan nanoparticles for improving drug delivery and efficacy | Zendy

Arun Kumar | Zendy; Natasha F. Cover | Zendy; Susana K. Lai-Yuen | Zendy; Anna K. Parsons | Zendy

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Synergetic effects of doxycycline-loaded chitosan nanoparticles for improving drug delivery and efficacy

Author(s) -

Arun Kumar,

Natasha F. Cover,

Susana K. Lai-Yuen,

Anna K. Parsons

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27328

Subject(s) - doxycycline , chitosan , antibiotics , drug , pharmacology , drug delivery , solid lipid nanoparticle , in vivo , particle size , materials science , chemistry , medicine , nanotechnology , biology , biochemistry , microbiology and biotechnology

Doxycycline, a broad-spectrum antibiotic, is the most commonly prescribed antibiotic worldwide for treating infectious diseases. It may be delivered orally or intravenously but can lead to gastrointestinal irritation and local inflammation. For treatment of uterine infections, transcervical administration of doxycycline encapsulated in nanoparticles made of biodegradable chitosan may improve sustained delivery of the drug, thereby minimizing adverse effects and improving drug efficacy.

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